A Drug Researcher Talks Michael Pollan's Book, PTSD Treatment And Trump On LSD. - May 25th, 2018 The Huffington Post 

Selected Papers 2015-2019



For a comprehensive bibliography including papers from all years, click HERE.

Weafer, J., J. DeArcangelis, H. de Wit (2015) Sex differences in behavioral impulsivity in at-risk and non-risk drinkers.  Frontiers in Neuroscience 6, 72. PMCID: PMC4429551

Weafer, J., S.H. Mitchell, H. de Wit  (2015) Recent translational findings on impulsivity in relation to drug abuse.  Current Addiction Reports, 1, 289-300. PMCID: PMC4323183

Bershad, A.K., J. H. Jaffe, E. Childs, H. de Wit (2015) Opioid partial agonist buprenorphine dampens responses to psychosocial stress in humans.  Psychoneuroendocrinology, 52, 281-8. PMCID: PMC4297554

Ballard, M.E., J. Weafer, D. Gallo, H. de Wit (2015) Methamphetamine-induced enhancement of emotional memory formation in humans: Encoding vs consolidation. PlosOne, 10. PMCID: PMC4332474

Mayo, L., H. de Wit (2015) Acquisition of responses to a methamphetamine-associated cue in healthy humans: self-report, behavioral, and psychophysiological measures. Neuropsychopharmacology, 40, 1734-41. PMCID: PMC4915257

Kirkpatrick, M.G., A.W. Delton, T.E. Robertson, H. de Wit (2015) Prosocial effects of MDMA:  A measure of generosity. Journal of Psychopharmacology, 29, 661-8. PMID: 25735993

Bershad, A.K., M.G. Kirkpatrick, J.A. Seiden, H. de Wit (2015) Effects of acute doses of prosocial drugs methamphetamine and alcohol on plasma oxytocin levels. Journal of Clinical Psychopharmacology, 35, 308-12. PMCID: PMC4414800

Baggott, M.J., M.G. Kirkpatrick, G. Bedi, H. de Wit. (2015) Intimate insight: MDMA changes how people talk about significant others.  J. Psychopharmacology, 29, 669-77. PMCID: PMC4698152

Yarosh, H.L., S.A. Meda, H. de Wit, A.B. Hart, G.D. Pearlson (2015) Multivariate analysis of subjective responses to d-amphetamine in healthy volunteers finds novel genetic pathway associations. Psychopharmacology, 2781-94. PMCID: PMC4504822

Hanlon, E.C., E. Tasali, R. Leproult, K Stuhr, E. Doncheck, H. de Wit, C.J. Hillard, E. Van Cauter (2015)  Circadian rhythm of circulating levels of endocannabinoid 2-arachidonoylglycerol. The Journal of Clinical Endocrinology & Metabolism, 100, 200-6. PMCID: PMC5399498

De Moor, M.H.M.,  … H. de Wit,… D.I. Boomsma (60 authors) (2015) Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder.  JAMA Psychiatry, 72, 642-50. PMCID: PMC4667957

Weafer, J, D Gallo, H. de Wit (2016) Alcohol effects on encoding and consolidation of memory for emotional stimuli.  Journal of Studies on Alcohol and Drugs. 77:86-94. PMCID: PMC4711324

Van den Berg, S.M., …H. de Wit,.. D.I. Boomsma (60 authors) (2016) Extraversion and common genetic variants: GWAS meta-analysis results from the Genetics of Personality Consortium.  Behavior Genetics. 46:170-82. doi: 10.1007/s10519-015-9735-5.  PMCID: PMC4751159

Miller, MA, AK Bershad, H de Wit. Drug effects on responses to emotional facial expressions: Recent findings.  Behavioural Pharmacology. 26:571-9. PMCID: PMC4905685

Bershad, AK, JJ Weafer, MG Kirkpatrick, MC Wardle, MA Miller, H de Wit (2016) Oxytocin receptor gene variation predicts subjective responses to MDMA. Social Neuroscience. 17:1-8. PMCID: PMC4988944

Bershad, AK, H de Wit. (2016) Effects of buprenorphine on responses to social stimuli in healthy adults.  Psychoneuroendocrinology. 63:43-9. PMCID: PMC4695221

Wardle, MC, AK Bershad, H de Wit (2016) Naltrexone alters the processing of social stimuli in healthy adults.  Social Neuroscience. 22:1-13. PMCID: PMC4958027

Kirkpatrick MG, Goldenson NI, Kapadia N, Kahler CW, de Wit H, Swift RM, McGeary JE, Sussman S, Leventhal AM. (2016) Emotional traits predict individual differences in amphetamine-induced positive mood in healthy volunteers. Psychopharmacology. 233:89-97. PMCID: PMC4703469

Wardle, MC, BA Marcus, H de Wit (2015) A preliminary investigation of individual differences in subjective responses to d-amphetamine, alcohol, and delta-9-tetrahydrocannabinol using a within-subjects randomized trial. PloS One. 10:e0140501. PMCID: PMC4626040

Temple, JL, AM Ziegler, H de Wit, C Martin (2015) Caffeine effects on subjective responses are influenced by caffeine dose, sex, and pubertal stage. Journal of Caffeine Research. 5:167-175. PMCID: PMC4663646

VanderBroek, L, J Acker, AA Palmer, H de Wit, J MacKillop (2016) Interrelationships between family history of substance misuse, impulsive delay discounting, and substance use. Psychopharmacology 233:39-48. PMCID: PMC4830143

Hanlon, EC, E Tasali, R Leproult, KL Stuhr, E Doncheck, H de Wit, CJ Hillard, E Van Cauter (2016) Sleep restriction enhances the daily rhythm of circulating levels of endocannabinoid 2-arachidonoylglycerol. Sleep. 39(3):653-664. PMCID: PMC4763355

Mayo, L, H de Wit (2016) Acquisition of conditioned responses to a novel alcohol-paired cue in social drinkers. Journal of Studies on Alcohol and Drugs, 77, 317-26. PMCID: PMC4803664

Smith, CT, J Weafer, RL Cowan, RM Kessler, AA Palmer, H de Wit, DH Zald (2016) Individual differences in timing of peak positive subjective responses to d-amphetamine: relationship to pharmacokinetics and physiology. J of Psychopharmacology, 30, 330-43.  PMCID: PMC5049703

Cavallo, J, N Ruiz, H de Wit (2016) Extinction of conditioned responses to methamphetamine-associated stimuli in healthy humans. Psychopharmacology 233, 2489-502. PMCID: PMC4909474

Weafer, J, D Gallo, H de Wit (2016) Effect of alcohol on encoding and consolidation of memory for alcohol-related images.  Alcoholism: Clinical and Experimental Research 40, 1540-7. PMCID: PMC4930409

Francis, SM, MG Kirkpatrick, H de Wit, S Jacob (2016) Urinary and plasma oxytocin changes in response to oxytocin releasing drugs. Psychoneuroendocrinology 74,92–100. PMID: 27592327

Childs, E, A Bershad and H de Wit (2016) Effects of d-amphetamine upon social stress responses. Journal of Psychopharmacology 30, 608-15. PMID: 27235381

MacKillop, J, J Weafer, J Gray, O Assaf, A Palmer, H de Wit (2016) The latent structure of impulsivity: Impulsive choice, impulsive action, and impulsive personality traits. Psychopharmacology 233, 3361-70. PMCID: PMC5204128

Cavallo, JS, LM Mayo, H de Wit (2016) Acquisition of conditioning between methamphetamine and cues in healthy humans. PLOSOne,11(8):e0161541. PMCID:PMC4993385

Miller, MA, A Bershad, A King, R Lee, H de Wit (2016) Intranasal oxytocin dampens cue-elicited cigarette craving in daily smokers.  Behavioural Pharmacology 27(8):697-703. PMCID: PMC5089916

Shaham, Y, H de Wit (2016) Lost in translation: CRF1 receptor antagonists and addiction treatmentCommentary, Neuropsychopharmacology 41:2795-2797. PMCID: PMC5061894

Miller, MA, AK Bershad, M Baggott, H de Wit (2016) MDMA as a social drug: Does it differ from other stimulants? J of Psychopharmacology 30:1248-1258. PMID: 27562198

Childs, E., R Astur, H de Wit (2017) Virtual reality conditioned place preference using monetary reward. Behavioural Brain Research. 322,110–114. PMCID: PMC5335910

Childs, E, H de Wit (2016) Alcohol-induced place conditioning in moderate social drinkers. Addiction 111:2157-2165. PMCID: PMC5226878

Bidwell, C, J MacKillop, AA Palmer, J Gray, J Weafer, H de Wit (2017) Genetic influences on ADHD symptom dimensions: Examination of a priori candidates, genome-wide variation, and SNP heritability. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 174:458-466. PMCID: PMC5690554

Childs, E, J Lutz, H de Wit. (2017) Dose-related effects of delta-9-tetrahydrocannabinol on emotional responses to acute stress. Drug and Alcohol Dependence, 177, 136-144.

Weafer, J, SM Gorka, D Hedeker, M Dzemidzic, DA Kareken, KL Phan, H de Wit (2017) Associations between behavioral and neural correlates of inhibitory control and amphetamine reward sensitivity. Neuropsychopharmacology 42, 1905-1913. PMCID: PMC5520786

Bershad, AK, MA Miller, H de Wit (2017) MDMA does not increase responses to acute psychosocial stress in humans. Psychopharmacology 234, 2159-2166

Arndt, DL, H de Wit (2017) Cannabidiol does not dampen responses to emotional stimuli in healthy adults. Cannabis and Cannabinoid Research 2:105-113. PMCID: PMC5569582

Weafer, J, N Lyon, D Hedeker, H de Wit (2017) Associations between sweet taste liking and subjective response to amphetamine in healthy men and women.  Psychopharmacology 234:3185-3194. PMCID: PMC5660927

Palmisano, AN, E Hudd, C McQuade, H de Wit, RS Astur (2018) The effects of nicotine on conditioning, extinction, and reinstatement in humans. Addictive Behaviors, 77, 51-58. PMID: 28957728

Gray, J. C., MacKillop, J., Weafer, J., Hernandez, K. M., Gao, J., Palmer, A. A., & de Wit, H. (2017). Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation. Psychiatry Research 259, 398-404. PMCID: PMC5742029

Crane, NA, SM Gorka, J Weafer, SA Langenecker, H de Wit, and KL Phan (2017) Preliminary evidence for disrupted nucleus accumbens reactivity and connectivity to reward in binge drinkers. Alcohol and Alcoholism 52, 647-654. PMCID: PMC5860287

Van Hedger, K, AK Bershad, H de Wit (2017) Pharmacological challenge studies with acute psychosocial stress. Psychoneuroendocrinology, 85,123-133. PMCID: PMC5623124

Weafer, J, JC Gray, K Hernandez, AA Palmer, J MacKillop, H de Wit (2017) Hierarchical investigation of genetic influences on response inhibition in healthy young adults: A Priori candidates, high value addiction markers, and genome-wide variation. Experimental and Clinical Psychopharmacology, 25: 512-520. PMCID: PMC5737791

Sanchez-Roige S, Fontanillas P, Elson SL, the 23andMe Research Team*, Pandit A, Schmidt E, Forster J, Abecasis GR, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA (2018) Genetics of the Research Domain Criteria (RDoC): genome-wide association study of delay discounting. Nature Neuroscience, 21: 16-18.  DOI 10.1038/s41593-017-0032.

Bershad, AK, NA Ruiz, H de Wit (2018) Effects of buprenorphine on responses to emotional stimuli in individuals with a range of mood symptomatology. Intl J Neuropsychopharmacol, 21, 120-127. PMCID: PMC5793829

Doss, MK, J Weafer, DA Gallo, H de Wit (2018) MDMA Impairs both the encoding and retrieval of emotional recollections.  Neuropsychopharmacology, 43, 791-800.  PMCID: PMC5809786

Sanchez-Roige, S, the 23andMe Research Team, JC Gray, H de Wit, J MacKillop, AA Palmer (2017) Genome-wide association study of Alcohol Use Disorder Identification Test (AUDIT) scores in 20,328 research participants of European ancestry. Addiction Biology, 1, 121-131. PMID:29058377

de Wit, H and MA Sayette (2018) Considering the context:  Social factors in responses to drugs in humans. Psychopharmacology 235, 935-945. PMCID: PMC5871591

Van Hedger, K, SK Keedy, L Mayo, M Heilig, H de Wit (2018) Neural responses to cues paired with methamphetamine in healthy volunteers. Neuropsychopharmacology, 43(8), 1732. PMCID: PMC6006246

Crane, N, S Gorka, J Weafer, S Langenecker, H de Wit, KL Phan (2018) Neural activation to monetary reward is associated with amphetamine reward sensitivity. Neuropsychopharmacology, 1. PMCID: PMC5871591

Bershad, AK, MA Miller, GJ Norman, and H de Wit (2018) Effects of opioid- and non-opioid analgesics on responses to psychosocial stress in humans. Hormones and Behavior, 102, 41-47. PMCID: PMC6004330

Van Hedger, K, R Lee, H de Wit (2018) Oxytocin reduces cigarette consumption in daily smokers. Nicotine and Tobacco Research, 1, 6. PMID:29701814

 Doss, MK, J Weafer, DA Gallo, H de Wit (2018) Δ9-Tetrahydrocannabinol at retrieval drives false recollection of neutral and emotional memories.  Biological Psychiatry. PMID: 29884456

de Wit, H, D Epstein, K Preston (2018) Does human language limit translatability of clinical and preclinical addiction research? Neuropsychopharmacology, 43(10), 1985. PMCID: PMC6098131

Vena, A, A King, R Lee, H de Wit (2018) Intranasal oxytocin does not modulate responses to alcohol in social drinkers. Alcoholism: Clinical and Experimental Research. PMCID: PMC6120762

MacKillop, J, JC Gray, J Weafer, S Sanchez-Roige, AA Palmer, & H de Wit, H. (2018). Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach. Experimental and Clinical Psychopharmacology, 27(1), 29-37. PMID: 30265060

Pasman, JA, K Verweij, Z Gerring, S Stringer, S Sanchez-Roige, J Treur, A Abdellaoui, MG Nivard, B Baselmans, JS Ong, H Ip, M van der Zee, M Bartels, F Day, P Fontanillas, S Elson, The 23andMe Research Team , H de Wit, L Davis, J MacKillop, The Substance Use Disorders Working Group of the Psychiatric Genomics Consortium N/A , The International Cannabis Consortium, J Derringer, S Branje, C Hartman, A Heath, P van Lier, P Madden, R Mägi, W Meeus, G Montgomery, A Oldehinkel, Z Pausova, J Ramos-Quiroga, T Paus, M Ribases, J Kaprio, MBoks , J Bell, T Spector, J Gelernter, D Boomsma, N Martin, S Macgregor, J Perry, AA Palmer, D Posthuma, M Munafo, N Gillespie, E Derks, JA Vink (2018) GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nature Neuroscience. PMCID: PMC6386176

Weafer, J, T Ross, S O’Connor, E Stein, H de Wit, E Childs (2018) Striatal activity correlates with stimulant-like effects of alcohol in healthy volunteers.  Neuropsychopharmacology, 1.  PMCID: PMC6224577

Doss, M. K., Weafer, J., Ruiz, N. A., Gallo, D. A., & De Wit, H. (2018). Alcohol and pharmacologically similar sedatives impair encoding and facilitate consolidation of both recollection and familiarity in episodic memory. Cognitive neuroscience9(3-4), 89-99. PMCID: PMC6309693

Van Hedger, K, R Lee, M. Kushner, H de Wit (2018) Effects of intranasal oxytocin on stress-induced cigarette craving in daily smokers.  Nicotine and Tobacco Research. PMID: 30085292

Walters, RK (many authors…), J Gelernter, HJ Edenberg, A Agrawal (2018) Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nature Neuroscience, 21, 1656-1669. PMCID: PMC6430207

Linner, RK (many authors…), JP Beauchamp (2018)  GWAS of risk tolerance and risky behaviors in over one million individuals identify hundreds of loci and reveal shared genetic influences. Nature Genetics, 1. PMID: 30643258

Van Hedger, K., Keedy, S. K., Schertz, K. E., Berman, M. G., & de Wit, H. (2019). Effects of methamphetamine on neural responses to visual stimuli. Psychopharmacology, 1-8. PMID: 30604184   

Sanchez-Roige, S, P Fontanillas, SL Elson, JC Gray, H de Wit, J MacKillop, AA Palmer Genome-wide association studies of impulsive personality traits (BIS-11 and UPPSP) and drug experimentation in up to 22,861 adult research participants. J. Neuroscience. doi:

 Weafer, J., Crane, N. A., Gorka, S. M., Phan, K. L., & de Wit, H. (2019). Neural correlates of inhibition and reward are negatively associated. NeuroImage. PMID: 30974242

 Pabon, E., MacKillop, J., & Palmer, A. A. (2019). Multidimensional latent structure of risk-related phenotypes in healthy young adults. Experimental and clinical psychopharmacology. PMID: 30998058

Gray, J. C., Sanchez-Roige, S., de Wit, H., MacKillop, J., & Palmer, A. A. (2019). Genomic Basis of Delayed Reward Discounting. Behavioural processes. PMID: 30876880  

Weafer, J, K Van Hedger, H de Wit (2019) Methamphetamine acutely alters frontostriatal resting state functional connectivity in healthy young adults. Addiction Biology.

Bershad, AK, LM Mayo, K Van Hedger, F McGlone, SC Walker, H de Wit (2019) Effects of MDMA on attention to positive social cues and pleasantness of affective touch. Neuropsychopharmacology.

King, AC, D Cao, H de Wit, SJ O’Connor, DS Hasin (2019) The role of alcohol response phenotypes in the risk for Alcohol Use Disorder.  Brit J Psych Open 5, e38, 1–3.