Interviews

A Drug Researcher Talks Michael Pollan's Book, PTSD Treatment And Trump On LSD. - May 25th, 2018 The Huffington Post 

Selected Papers 2014-2018

 

 

For a comprehensive bibliography including papers from all years, click HERE.

Ballard, E., D. Gallo, H. de Wit (2014) Amphetamine increases errors during episodic memory retrieval. Journal of Clinical Psychopharmacology, 34, 85-92 PMC4244906

Frye, C.G., M.C. Wardle, G.J. Norman, H. de Wit (2014) MDMA decreases the effects of simulated social rejection.  Pharmacology, Biochemistry and Behavior, 117, 1-6. PMC3910346

Weafer, J., D.Gallo, H. de Wit (2014) Amphetamine fails to alter cued recollection of emotional images: Study of encoding, retrieval, and state-dependency. Plos One 9 PMC3937372

Kirkpatrick, M.G., S. M. Francis, R. Lee, H. de Wit, S. Jacob (2014)  Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans. Psychoneuroendocrinology, 46, 23-31. PMC4088952

Childs, E., H. de Wit (2014) Regular exercise is associated with emotional resilience to acute stress in healthy adults. Frontiers in Physiology 5, 161. PMC4013452
                                                                                                                                  Wardle, M.C., H. de Wit (2014)  MDMA alters emotional processing and facilitates social interaction.  Psychopharmacology.  PMC4194242

Hart, A.B., E.R. Gamazon, B. E. Engelhardt, P. Sklar, C. Hultman, Pa. F. Sullivan, B. Neale, S.V. Faraone, Psychiatric Genomics Consortium: ADHD Subgroup, H. de Wit, N. J. Cox, A.A. Palmer (2014)  Genetic variation associated with the euphorigenic effects of d-amphetamine is also associated with diminished risk for schizophrenia and ADHD. Proceedings of the National Academy of Sciences, 111, 5968-73.  PMC4000861

Clark, D.B., H. de Wit, W. Iacono (2014) ADHD, Impulsivity and Substance Abuse: Methods, Results and Implications. Experimental and Clinical Psychopharmacology, 22, 141-3. PMC4141644

Kirkpatrick, M., R. Lee, M. Wardle, S. Jacob, H. de Wit (2014) Effects of MDMA and intranasal oxytocin on social and emotional processing. Neuropsychopharmacology. 39, 1654-63. PMC4088952

Childs, E., T.L. White, H. de Wit (2014) Personality traits modulate subjective and physiological responses to stress. Behavioural Pharmacology 25, 493-502. PMC4119514

Kirkpatrick, M.G., M.J. Baggott, J.E. Mendelson, G.P. Galloway, M.E Liechti, C.M Hysek, H. de Wit. (2014) MDMA effects consistent across controlled laboratory settings. Psychopharmacology 231, 3899–3905.   PMC4161650

Weafer, J. A. Burkhardt, H. de Wit (2014) Sweet taste liking associated with impulsive behaviors in humans. Frontiers in Behavioral Neuroscience, 8, 228. PMC4060557

Weafer, J. and H. de Wit. (2014) Sex differences in impulsive action and impulsive choice.  Addictive Behaviors 39, 1573-9 PMC4012004

Wardle, M.C., M.G. Kirkpatrick, H. de Wit (2014) “Ecstasy” as a social drug: MDMA preferentially affects responses to emotional stimuli with social content.  Social Cognitive and Affective Neuroscience 9, 1076-81. PMCID: PMC4127030

Bedi, G, G. Cecchi, D.F. Slezak, F. Carrillo, M. Sigma, H. de Wit (2014) A window into the intoxicated mind:  Speech as an index of psychoactive drug effects.  Neuropsychopharmacology, 39, 2340-8. PMCID: PMC4138742

Kirkpatrick, M.G. and H. de Wit (2015) MDMA: a social drug in a social context. Psychopharmacology, 232, 1155-1163. PMCID: PMC4339498

Clark, C.M., D.G. Frye, M.C. Wardle, G.J. Norman, H. de Wit (2015) Acute effects of MDMA on autonomic cardiac activity and their relation to subjective pro-social and stimulant effects.  Psychophysiology, 52:429-35. PMCID: PMC4634859

Gorka, S.M., Fitzgerald, D.A., de Wit, H., & Phan, K.L. (2014) Cannabinoid modulation of amygdala subregion functional connectivity to social signals of threat. The International Journal of Neuropsychopharmacology 28, 18. PMCID: PMC4360235

Gorka, S., D. Fitzgerald, M. Angstadt, H. de Wit, K.L. Phan (2014)  Opioid modulation of resting-state anterior cingulate cortex functional connectivity. Journal of Psychopharmacology, 28, 1115-24 PMID: 25237122

Weafer, J., J. DeArcangelis, H. de Wit (2015) Sex differences in behavioral impulsivity in at-risk and non-risk drinkers.  Frontiers in Neuroscience 6, 72. PMCID: PMC4429551

Weafer, J., S.H. Mitchell, H. de Wit  (2015) Recent translational findings on impulsivity in relation to drug abuse.  Current Addiction Reports, 1, 289-300. PMCID: PMC4323183

Bershad, A.K., J. H. Jaffe, E. Childs, H. de Wit (2015) Opioid partial agonist buprenorphine dampens responses to psychosocial stress in humans.  Psychoneuroendocrinology, 52, 281-8. PMCID: PMC4297554

Ballard, M.E., J. Weafer, D. Gallo, H. de Wit (2015)  Methamphetamine-induced enhancement of emotional memory formation in humans: Encoding vs consolidation. PlosOne, 10. PMCID: PMC4332474

Mayo, L., H. de Wit (2015) Acquisition of responses to a methamphetamine-associated cue in healthy humans: self-report, behavioral, and psychophysiological measures. Neuropsychopharmacology, 40, 1734-41. PMID: 25601231 [PubMed - in process].

Kirkpatrick, M.G., A.W. Delton, T.E. Robertson, H. de Wit (2015) Prosocial effects of MDMA:  A measure of generosity. Journal of Psychopharmacology, 29, 661-8. PMID: 25735993

Bershad, A.K., M.G. Kirkpatrick, J.A. Seiden, H. de Wit (2015) Effects of acute doses of prosocial drugs methamphetamine and alcohol on plasma oxytocin levels. Journal of Clinical Psychopharmacology, 35, 308-12. PMCID: PMC4414800

Baggott, M.J., M.G. Kirkpatrick, G. Bedi, H. de Wit. (2015) Intimate insight: MDMA changes how people talk about significant others.  J. Psychopharmacology, 29, 669-77. PMCID: PMC4698152


Yarosh, H.L., S.A. Meda, H. de Wit, A.B. Hart, G.D. Pearlson (2015) Multivariate analysis of subjective responses to d-amphetamine in healthy volunteers finds novel genetic pathway associations. Psychopharmacology, 2781-94. PMCID: PMC4504822

Hanlon, E.C., E. Tasali, R. Leproult, K Stuhr, E. Doncheck, H. de Wit, C.J. Hillard, E. Van Cauter (2015)  Circadian rhythm of circulating levels of endocannabinoid 2-arachidonoylglycerol. The Journal of Clinical Endocrinology & Metabolism, 100, 200-6. PMID: 25368979 


De Moor, M.H.M.,  … H. de Wit,… D.I. Boomsma (60 authors) (2015) Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder.  JAMA Psychiatry, 72, 642-50. PMCID: PMC4667957

Weafer, J, D Gallo, H. de Wit (2016) Alcohol effects on encoding and consolidation of memory for emotional stimuli.  Journal of Studies on Alcohol and Drugs. 77:86-94. PMCID: PMC4711324

Van den Berg, S.M., …H. de Wit,.. D.I. Boomsma (60 authors) (2016) Extraversion and common genetic variants: GWAS meta-analysis results from the Genetics of Personality Consortium.  Behavior Genetics. 46:170-82. doi: 10.1007/s10519-015-9735-5.  PMCID: PMC4751159

Miller, MA, AK Bershad, H de Wit. Drug effects on responses to emotional facial expressions: Recent findings.  Behavioural Pharmacology. 26:571-9. PMCID: PMC4905685

Bershad, AK, JJ Weafer, MG Kirkpatrick, MC Wardle, MA Miller, H de Wit (2016)  Oxytocin receptor gene variation predicts subjective responses to MDMA. Social Neuroscience. 17:1-8. PMID: 26787430

Bershad, AK, H de Wit. (2016) Effects of buprenorphine on responses to social stimuli in healthy adults.  Psychoneuroendocrinology. 63:43-9. PMCID: PMC4695221

Wardle, MC, AK Bershad, H de Wit (2016) Naltrexone alters the processing of social stimuli in healthy adults.  Social Neuroscience. 22:1-13. PMID: 26710657 PMCID: PMC4958027

Kirkpatrick MG, Goldenson NI, Kapadia N, Kahler CW, de Wit H, Swift RM, McGeary JE, Sussman S, Leventhal AM. (2016) Emotional traits predict individual differences in amphetamine-induced positive mood in healthy volunteers. Psychopharmacology. 233:89-97. PMCID: PMC4703469

Wardle, MC, BA Marcus, H de Wit (2015) A preliminary investigation of individual differences in subjective responses to d-amphetamine, alcohol, and delta-9-tetrahydrocannabinol using a within-subjects randomized trial. PloS One. 10:e0140501. PMCID: PMC4626040

Temple, JL, AM Ziegler, H de Wit, C Martin (2015) Caffeine effects on subjective responses are influenced by caffeine dose, sex, and pubertal stage. Journal of Caffeine Research. 5:167-175. PMCID: PMC4663646

VanderBroek, L, J Acker, AA Palmer, H de Wit, J MacKillop (2016)  Interrelationships between family history of substance misuse, impulsive delay discounting, and substance use. Psychopharmacology 233:39-48. PMID: 26395990  PMCID: PMC4830143

Hanlon, EC, E Tasali, R Leproult, KL Stuhr, E Doncheck, H de Wit, CJ Hillard, E Van Cauter (2016) Sleep restriction enhances the daily rhythm of circulating levels of endocannabinoid 2-arachidonoylglycerol. Sleep. 39(3):653-664. PMCID: PMC4763355

Mayo, L, H de Wit (2016) Acquisition of conditioned responses to a novel alcohol-paired cue in social drinkers. Journal of Studies on Alcohol and Drugs, 77, 317-26. PMID: 26997190

Smith, CT, J Weafer, RL Cowan, RM Kessler, AA Palmer, H de Wit, DH Zald (2016) Individual differences in timing of peak positive subjective responses to d-amphetamine: relationship to pharmacokinetics and physiology. J of Psychopharmacology, 30, 330-43.  PMID: 26880226

Cavallo, J, N Ruiz, H de Wit (2016) Extinction of conditioned responses to methamphetamine-associated stimuli in healthy humans. Psychopharmacology 233, 2489-502. PMCID: PMC4909474

Weafer, J, D Gallo, H de Wit (2016) Effect of alcohol on encoding and consolidation of memory for alcohol-related images.  Alcoholism: Clinical and Experimental Research 40, 1540-7. PMCID: PMC4930409

Childs, E., R Astur, H de Wit (2017) Virtual reality conditioned place preference using monetary reward. Behavioural Brain Research. 322,110–114. PMCID: PMC5335910

Childs, E, H de Wit (2016) Alcohol-induced place conditioning in moderate social drinkers. Addiction 111:2157-2165. PMCID: PMC5226878

Bidwell, C, J MacKillop, AA Palmer, J Gray, J Weafer, H de Wit (2017) Genetic influences on ADHD symptom dimensions: Examination of a priori candidates, genome-wide variation, and SNP heritability. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 174:458-466. PMCID: PMC5690554

Childs, E, J Lutz, H de Wit. (2017) Dose-related effects of delta-9-tetrahydrocannabinol on emotional responses to acute stress. Drug and Alcohol Dependence, 177, 136-144.

Weafer, J, SM Gorka, D Hedeker, M Dzemidzic, DA Kareken, KL Phan, H de Wit (2017) Associations between behavioral and neural correlates of inhibitory control and amphetamine reward sensitivity. Neuropsychopharmacology 42, 1905-1913. PMCID: PMC5520786

Bershad, AK, MA Miller, H de Wit (2017) MDMA does not increase responses to acute psychosocial stress in humans. Psychopharmacology 234, 2159-2166

Arndt, DL, H de Wit (2017) Cannabidiol does not dampen responses to emotional stimuli in healthy adults. Cannabis and Cannabinoid Research 2:105-113. PMCID: PMC5569582

Weafer, J, N Lyon, D Hedeker, H de Wit (2017) Associations between sweet taste liking and subjective response to amphetamine in healthy men and women.  Psychopharmacology 234:3185-3194. PMCID: PMC5660927

Palmisano, AN, E Hudd, C McQuade, H de Wit, RS Astur (2018) The effects of nicotine on conditioning, extinction, and reinstatement in humans. Addictive Behaviors, 77, 51-58.

Gray, J. C., MacKillop, J., Weafer, J., Hernandez, K. M., Gao, J., Palmer, A. A., & de Wit, H. (2017). Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation. Psychiatry Research 259, 398-404. PMCID: PMC5742029

Crane, NA, SM Gorka, J Weafer, SA Langenecker, H de Wit, and KL Phan (2017) Preliminary evidence for disrupted nucleus accumbens reactivity and connectivity to reward in binge drinkers. Alcohol and Alcoholism 52, 647-654. PMCID: PMC5860287

Van Hedger, K, AK Bershad, H de Wit (2017) Pharmacological challenge studies with acute psychosocial stress. Psychoneuroendocrinology, 85,123-133. PMCID: PMC5623124

Weafer, J, JC Gray, K Hernandez, AA Palmer, J MacKillop, H de Wit (2017) Hierarchical investigation of genetic influences on response inhibition in healthy young adults: A Priori candidates, high value addiction markers, and genome-wide variation. Experimental and Clinical Psychopharmacology, 25: 512-520. PMCID: PMC5737791

Sanchez-Roige S, Fontanillas P, Elson SL, the 23andMe Research Team*, Pandit A, Schmidt E, Forster J, Abecasis GR, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA (2018) Genetics of the Research Domain Criteria (RDoC): genome-wide association study of delay discounting. Nature Neuroscience, 21: 16-18.  DOI 10.1038/s41593-017-0032.

Bershad, AK, NA Ruiz, H de Wit (2018) Effects of buprenorphine on responses to emotional stimuli in individuals with a range of mood symptomatology. Intl J Neuropsychopharmacol, 21, 120-127. PMCID: PMC5793829

Doss, MK, J Weafer, DA Gallo, H de Wit (2018) MDMA Impairs both the encoding and retrieval of emotional recollections.  Neuropsychopharmacology, 43, 791-800.  PMCID: PMC5809786

Sanchez-Roige, S, the 23andMe Research Team, JC Gray, H de Wit, J MacKillop, AA Palmer (2017) Genome-wide association study of Alcohol Use Disorder Identification Test (AUDIT) scores in 20,328 research participants of European ancestry. Addiction Biology. doi: 10.1111/adb.12574. [Epub ahead of print] PMID:29058377

de Wit, H and MA Sayette (2018) Considering the context:  Social factors in responses to drugs in humans. Psychopharmacology 235, 935-945. PMCID: PMC5871591

Van Hedger, K, S Keedy, L Mayo, M Heilig, H de Wit (2018) Neural responses to cues paired with methamphetamine in healthy volunteers. Neuropsychopharmacology

Doss, MK, J Weafer, DA Gallo, H de Wit (2018) Δ9-Tetrahydrocannabinol at retrieval drives false recollection of neutral and emotional memories.  Biological Psychiatry.

de Wit, H, D Epstein, K Preston (2018) Does human language limit translatability of clinical and preclinical addiction research? Neuropsychopharmacology.

Vena, A, A King, R Lee, H de Wit (2018) Intranasal oxytocin does not modulate responses to alcohol in social drinkers. Alcoholism: Clinical and Experimental Research.

MacKillop, J, JC Gray, J Weafer, S Sanchez-Roige, AA Palmer, & H de Wit, H. (2018). Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach. Experimental and Clinical Psychopharmacology

Vink, J Pasman, J, K Verweij, Z Gerring, S Stringer, S Sanchez-Roige, J Treur, A Abdellaoui, MG Nivard, B Baselmans, JS Ong, H Ip, M van der Zee, M Bartels, F Day, P Fontanillas, S Elson, The 23andMe Research Team , H de Wit, L Davis, J MacKillop, The Substance Use Disorders Working Group of the Psychiatric Genomics Consortium N/A , The International Cannabis Consortium, J Derringer, S Branje, C Hartman, A Heath, P van Lier, P Madden, R Mägi, W Meeus, G Montgomery, A Oldehinkel, Z Pausova, J Ramos-Quiroga, T Paus, M Ribases, J Kaprio, MBoks , J Bell, T Spector, J Gelernter, D Boomsma, N Martin, S Macgregor, J Perry, AA Palmer, D Posthuma, M Munafo, N Gillespie, E Derks (2018) GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nature Neuroscience.

Weafer, J, T Ross, S O’Connor, E Stein, H de Wit, E Childs (2018) Striatal activity correlates with stimulant-like effects of alcohol in healthy volunteers.  Neuropsychopharmacology.

Doss, M, J Weafer, N Ruiz, D Gallo, H de Wit (2018) Alcohol impairs encoding and facilitates consolidation of both recollection and familiarity in episodic memory. Cognitive Neuroscience. 10.1080/17588928.2018.1504764

Van Hedger, K, R Lee, M. Kushner, H de Wit (2018) Effects of intranasal oxytocin on stress-induced cigarette craving in daily smokers.  Nicotine and Tobacco Research.