http://hbpl.uchicago.edu/what-are-we-doing daily 0.75 2024-11-07 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1667834863868-GR8H7X7E7QM8PL0Z6CI1/Picture1.jpg What Are We Doing? http://hbpl.uchicago.edu/what-are-we-doing/2024/11/7/repeated-lose-doses-of-lsd monthly 0.5 2024-11-18 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/389dcaca-c62b-46d2-b0ca-432ffb03db8a/thumbnail_image001.png What Are We Doing? - Repeated low doses of LSD - Make it stand out Whatever it is, the way you tell your story online can make all the difference. http://hbpl.uchicago.edu/what-are-we-doing/2024/8/14/lsd-and-depression-is-microdosing-the-new-antidepressant monthly 0.5 2024-08-14 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/8311b407-6271-4e04-b113-1a3456b6ece1/LSD_article_image2.png What Are We Doing? - LSD and Depression: is Microdosing the new Antidepressant? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/fb79f673-edff-4eae-a6cd-0571566a0c3d/LSD_article_image.png What Are We Doing? - LSD and Depression: is Microdosing the new Antidepressant? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. http://hbpl.uchicago.edu/what-are-we-doing/2022/11/7/what-does-an-lsd-microdose-do-to-brain-function monthly 0.5 2022-11-07 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/d6aeaf1a-79b7-4db5-a4b9-d8746e9c710f/Picture1.jpg What Are We Doing? - What does an LSD microdose do to brain function? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. http://hbpl.uchicago.edu/what-are-we-doing/2022/5/20/nothing-without-love-matters-can-mdma-change-sociopolitical-values monthly 0.5 2022-05-20 http://hbpl.uchicago.edu/what-are-we-doing/2022/5/3/lsd-the-new-antidepressant monthly 0.5 2022-05-03 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/52634a97-aef4-4881-9203-ca78049ba981/lsd-universal-832x469.jpg What Are We Doing? - LSD: the new antidepressant? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. http://hbpl.uchicago.edu/what-are-we-doing/2022/4/22/women-and-weed monthly 0.5 2022-05-12 http://hbpl.uchicago.edu/what-are-we-doing/2021/5/12/why-do-healthy-people-choose-to-use-d-amphetamine monthly 0.5 2021-05-12 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1620820376359-SSUG2S3PIVIA4HCIB4A0/Smiley+Face.jpg What Are We Doing? - Why do healthy people choose to use d-amphetamine? - Make it stand out Many previous studies reviewed by this laboratory found that experiencing pleasure or euphoria after using stimulants like d-amphetamine predicts future usage. http://hbpl.uchicago.edu/what-are-we-doing/2020/2/25/how-does-thc-affect-your-memory monthly 0.5 2020-02-25 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1582664332229-2J8ZDDV07HCIJLAIK8LW/Memory+Loss.jpeg What Are We Doing? - How does THC affect your memory? Impaired memory is a common side effect of cannabis consumption. https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1582665185857-ZQFJPVHC33PGOZPSPAPU/Screen+Shot+2020-02-25+at+3.12.36+PM.png What Are We Doing? - How does THC affect your memory? False memory refers to cases in which people remember events differently from the way they happened or even events that never happened at all. These can be extremely vivid and held with high confidence. https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1582664450477-IZ5KZF2B8HJBKV660F2B/Screen+Shot+2020-02-25+at+3.00.25+PM.png What Are We Doing? - How does THC affect your memory? This study provides evidence that THC impairs memory of perceptual details of objects. This is important in the case of eyewitness testimonies, where distorted memories could be damaging. http://hbpl.uchicago.edu/what-are-we-doing/2020/1/21/does-oxytocin-dampen-stress-induced-cigarette-cravings-well-we-still-dont-know monthly 0.5 2020-01-21 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1579638316093-0A0749H19JL3FTAQ0XFF/Love+Oxytocin.jpg What Are We Doing? - Can oxytocin dampen stress-induced cigarette cravings? Oxytocin is a hormone nicknamed the love hormone because of its’ role in bonding. In a 2003 study, both humans and dog oxytocin levels in the blood rose after five to 24 minutes of a petting session. https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1579638862832-QXVXH4ZVSLNVWRWUOIW6/stress+response+system.jpg What Are We Doing? - Can oxytocin dampen stress-induced cigarette cravings? Cortisol is the result of the body’s stress response system. In our study, we measured subject’s cortisol to gather information on their stress levels. http://hbpl.uchicago.edu/what-are-we-doing/2019/11/13/what-if-you-could-predict-and-possibly-prevent-impulsive-and-addictive-behaviors-such-as-drug-and-alcohol-addiction-binge-eatingobesity-and-problem-gambling monthly 0.5 2019-11-13 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1573668097253-XKWK78HQ9YT3JMJBX99L/RiskFactors.jpg What Are We Doing? - What if you could predict, and possibly prevent, impulsive and addictive behaviors such as drug and alcohol addiction, binge eating/obesity, and problem gambling? https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1573667558494-LOPO9RY4XJ8ODMJSXVHH/bing+drinking.jpg What Are We Doing? - What if you could predict, and possibly prevent, impulsive and addictive behaviors such as drug and alcohol addiction, binge eating/obesity, and problem gambling? Binge drinkers are at a higher risk for developing substance abuse disorders. In our study, binge drinkers had a more pronounced negative correlation between brain activation during inhibition and reward, which supports the idea that inhibition and reward reactivity are related at the neural level and could be risk factors for drug use. https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1573667375180-D67KZJY4AWX3INY60YV1/Inhibition+vs.+reward.jpg What Are We Doing? - What if you could predict, and possibly prevent, impulsive and addictive behaviors such as drug and alcohol addiction, binge eating/obesity, and problem gambling? Our study found that an imbalance between inhibition and reward circuitry may be a risk factor or cause for problematic behaviors. http://hbpl.uchicago.edu/what-are-we-doing/2019/10/30/how-does-methamphetamine-affect-neural-response-in-our-brains monthly 0.5 2019-11-13 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1572451258324-H332KAIVEWYAKJD14NFR/Crystal+Meth.jpg What Are We Doing? - How does methamphetamine affect neural response to visual stimuli? When we say methamphetamine, you may think of something like this—commonly known as crystal meth. However, methamphetamine itself is a man-made stimulant similar to amphetamine (a more common drug name you know) that is approved for treatment for ADHD (Desoxyn) and some treatment for obesity. We administer the drug (acquired from professional pharmacology labs after receiving IRB approval) orally in a pill form and under supervised conditions. https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1572452044232-Q5SX11DFS4F6WYMTCFN2/the-senses.jpg What Are We Doing? - How does methamphetamine affect neural response to visual stimuli? Sensory processing is the process that organizes sensation from one’s own body and the environment, thus making it possible to use the body effectively within the environment. https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1572452431395-YQ5SQLWZGMGTXJDD4L1V/brain.jpg What Are We Doing? - How does methamphetamine affect neural response to visual stimuli? Under placebo conditions, activation in the areas of the brain that deal with visual processing was greater when shown high NSE images. However, once drug was administered, the drug had a greater effect on activation in these areas when subjects viewed low NSE images. http://hbpl.uchicago.edu/what-are-we-doing/2019/10/9/could-a-history-of-hypomanic-experiences-affect-someones-chances-of-developing-a-substance-use-disorder monthly 0.5 2019-11-13 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1570640182420-BCJCCOJ4LNXWWSDW7I86/brain+.jpg What Are We Doing? - Could a history of hypomanic experiences potentially affect the chances of developing a substance use disorder? We studied young adults with a history of hypomanic episodes or mood elevations— a history of having repeated, exaggerated highs and lows in mood. https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1570639880852-AFEO7YEH51ZHW2TM1D6T/amphetmines.jpg What Are We Doing? - Could a history of hypomanic experiences potentially affect the chances of developing a substance use disorder? Dextroamphetamine, known as d-amphetamine, is commonly used to treat ADHD and narcolepsy. It is also a commonly abused substance. http://hbpl.uchicago.edu/what-are-we-doing/2019/9/20/podcast-effects-of-mdma-on-attention-to-positive-social-cues-and-pleasantness-of-affective-touch monthly 0.5 2019-09-20 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1569001071407-5CQJH79DHB6ZVGLE9F32/268x0w.jpg What Are We Doing? - PODCAST: Effects of MDMA on attention to positive social cues and pleasantness of affective touch http://hbpl.uchicago.edu/what-are-we-doing/2019/8/13/could-microdosing-lsd-make-you-happier monthly 0.5 2019-11-13 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1566236974108-CV5NC0E5B04ESMXRCOBS/LSD+Tab+Image.jpg What Are We Doing? - Could microdosing LSD make you happier? https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1566236732217-G8HT3L9RE1CWYOLRXXD9/Moods.png What Are We Doing? - Could microdosing LSD make you happier? http://hbpl.uchicago.edu/what-are-we-doing/phoneappstudy monthly 0.5 2020-08-21 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1565188242025-XLI8I320WGBKDCTHFI7Q/Breathalyzer.jpg What Are We Doing? - Phone app that tells you how high you are? Biochemical measures, like Breath Alcohol Content (BAC), do not exist for detecting cannabis use. Tools currently on the market, such as the standardized field sobriety test or cannabis/THC breathalyzers, are ineffective as roadside measurements of driving under the influence. We wish it was that easy! https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1565189304817-4549IE8FW5DMBOL1N30T/Cannabis+Image.jpg What Are We Doing? - Phone app that tells you how high you are? Why not let people just smoke weed? Scientists need to maintain the same conditions across all participants in studies. Using smoked cannabis requires careful consideration of strain and standardizing how much is smoked. This would have led to far too many inaccuracies, plus our results would be restrained to that specific strain! https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1565188081920-9ER9FWZVTGQKOWWZGMED/Phone+Photo.jpg What Are We Doing? - Phone app that tells you how high you are? http://hbpl.uchicago.edu/participate daily 0.75 2022-08-11 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1475869177298-31QBD9KQUBUD900B4GP2/raised_hands.jpg Participate http://hbpl.uchicago.edu/directions daily 0.75 2022-08-11 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1475868740398-5SJTWGZNXPRQC29ZRSN8/Harper_Midway_Chicago.jpg Directions https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/6a4b0ecc-8593-4702-b745-c58ba3f94e3e/Entrance+Lab.jpg Directions - Make it stand out Whatever it is, the way you tell your story online can make all the difference. http://hbpl.uchicago.edu/papers daily 0.75 2025-04-03 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1475870776458-FE80QU879E5BXDCVP1KC/old_books.jpg Published Research http://hbpl.uchicago.edu/alumni daily 0.75 2025-04-04 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/8484229c-e0b4-49ed-9a15-cb5d4b7bc61c/Jason.jpg Alumni - Jason Cruz Former HBPL research assistant as part of NIH-funded U-RISE program Current undergraduate Biomedical Sciences Student at Marquette University https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/bafe6920-2af0-4cdf-8392-f67708c393e2/joe+debrosse.jpg Alumni - Joe DeBrosse Former HBPL research assistant. Current Data Science Analyst in the Psychiatry Department at Ohio State University https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/fdb6f382-3120-46e1-9981-d3ed5aa5c8f0/ilaria.jfif Alumni - Ilaria Tare Former HBPL research assistant. Current research Assistant in the Keenan Lab at University of Chicago https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/6bd89680-007f-4286-a9d1-730a2b9547a7/Connor.jpg Alumni - Dr. Connor Haggarty Postdoctoral Scholar at Wayne State University (Social Media) https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1534178891706-ZFGJME44F6AJEKKKEM6Y/emma_childs.jpg Alumni - Emma Childs Associate Professor of Psychiatry Department of Psychiatry University of Illinois at Chicago https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1534178927269-9FQ3XB1NBRCWCQUFCT6L/LeahMayo1.jpg Alumni - Leah Mayo Currently Assistant Professor Parker Research Chair in Psychedelics; Lead, Novel Therapeutics Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute Department of Psychiatry, University of Calgary https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1534178961362-0ZRKN4INWLDAFGNLHWEG/joel.jpg Alumni - Joel Cavallo Senior Regional Medical Advisor at Myovant Sciences. https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1534178788490-V7E6JGDN6LYGNZ15IS5M/Anya_Bershad.jpg Alumni - Anya Bershad Assistant Professor of Psychiatry at UCLA https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1534179108888-GM8X9WKKIT44IQ40ZOYF/D+Arndt+-+ASCPT+2018.jpg Alumni - David Arndt Medical Science Liasion, Neuropsychiatry at Biogen https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1534179191932-3818LP7CTBQVKOE7JQ2L/kasey_crop.jpg Alumni - Kasey Van Hedger Postdoctoral associate at Western University, Ontario, Canada https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1534188443097-40PGIOAUDXN9AP1OPKF4/manoj.jpg Alumni - Dr. Manoj Doss Postdoctoral research fellow at Johns Hopkins Center for Psychedelic and Consciousness research https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1564679252851-GDQP8MQII1IVKZWPG12G/Scott.jpg Alumni - Scott Schepers Director, Field Medical at Pear Therapeutics http://hbpl.uchicago.edu/juniorfaculty daily 0.75 2025-04-04 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/46f6cb64-93bb-42d9-bbaf-c27812bde2df/hanna.jpg Junior Faculty - Dr. Hanna Molla Dr. Molla completed her PhD in Pharmacology where she studied the role of the endocannabinoid system on prefrontal cortical function and the impact of adolescent cannabinoid exposure on prefrontal cortex development. She is currently an Instructor in the department under the mentorship of Dr. Harriet de Wit and she is interested in studying the neural and cognitive effects of drug use in humans, with a particular interest in cannabinoids and psychedelic compounds. She was awarded a Clinical and Translational Award through the ITM - UChicago. Her KL2 research examines the effects of THC on emotional memories in healthy adults. http://hbpl.uchicago.edu/dr-harriet-de-wit daily 0.75 2025-04-04 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1568377272396-VHOJOSE7KJ8IWE8M69WS/hdw.jpg Dr. Harriet de Wit http://hbpl.uchicago.edu/staff-volunteers daily 0.75 2025-04-04 http://hbpl.uchicago.edu/new-page daily 0.75 2025-05-27 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/a74989f8-586a-4134-a546-2b1dec0a1fda/emma_website.jpeg Research Assistants - Evan Hahn . Evan Hahn earned a BA in neuroscience and psychology from Oberlin College. Evan is interested in researching individual and conditional differences in social decision-making using neuroimaging, psychophysiological recordings, and computational modeling. Evan has been accepted into the Behavioral Neuroscience doctoral program at University of Alabama at Birmingham to begin fall 2025. https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/bf212cad-fac1-4d7c-8761-7dbd86d30a79/Gabriella_Bann_Headshot.jpg Research Assistants Gabriella Bann Gabriella recently completed an M.A. in Social Science with a concentration in Psychology at the University of Chicago, where they studied the impact of discrepant self-esteem and self-concept clarity on depressive symptoms. They previously attained a B.A. in Psychological & Brain Science and a B.S. in Environmental & Sustainability Science from George Washington University. They are interested in researching clinical intervention applications of psychedelic compounds and cannabinoids, including antidepressant and anxiolytic implementations. http://hbpl.uchicago.edu/company-1 daily 1.0 2022-08-03 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1475695604865-NOP2YDQRRHXZ031D64MH/pills2.jpg de Wit Lab Staff http://hbpl.uchicago.edu/training-mentorship daily 0.75 2016-12-06 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1476906092072-9CB9A3ACQ4GDSV2YFCQ9/group_hbpl.jpg More Information for Training https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1481046777329-I4V5E1HIMGIWLOV5JJTC/image-asset.jpeg More Information for Training http://hbpl.uchicago.edu/collaborators-1 daily 0.75 2025-04-03 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1477319976507-E2E50VNGZP1TOM1DBVM3/royce Collaborators https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1476899125650-8UW2IDGR68ODLC3SGXIE/Arndt.David+picture.jpg Collaborators https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1477319939019-AKYJYIQNJ916EJE621MH/greg-norman.jpg Collaborators https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1477320091043-D47SB7RNWSEFSSWQ0NAK/image-asset.jpeg Collaborators https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/4ca98a93-420b-4fc7-8f80-98f97501a901/weafer_headshot.jpg Collaborators - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/b4da031f-fe83-4e2a-8370-765df667e76c/NataniaCraine-old.jpg Collaborators - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/48af7425-21b4-40d6-84f2-04bace1b9ff0/siri-02-e1641228396435.jpeg Collaborators - Make it stand out Whatever it is, the way you tell your story online can make all the difference. http://hbpl.uchicago.edu/papers-1 daily 0.75 2016-10-24 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/1475870776458-FE80QU879E5BXDCVP1KC/old_books.jpg Published Research http://hbpl.uchicago.edu/new-page-2 daily 0.75 2025-06-26 https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/fc499166-a6ef-4241-82a0-b63006958ecb/hdw.jpg Festschrift for Harriet de Wit - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/57f5409e725e25ac19fd3af5/4ed4e9b6-3839-4a5f-a4d9-baedddd50b96/Festschrift+sched.png Festschrift for Harriet de Wit - Make it stand out Whatever it is, the way you tell your story online can make all the difference. http://hbpl.uchicago.edu/read-me daily 0.75 2025-05-12 https://images.squarespace-cdn.com/content/v1/5310cef7e4b08602cbfa36bf/1412689652885-P9TPK298WCTZU748L0SG/Lifestyle03.jpg Read Me